姜黄素-PLA 复合薄膜的制备及性能研究

郭 慧,吴济宏*

主办:上海医药工业研究院
   中国药学会
   中国化学制药工业协会
ISSN 1001-8255   CN 31-1243/R   ZYGZEA
中国医药工业杂志 ›› 2013, Vol. 44 ›› Issue (9) : 896-899.
药物制剂 Pharmaceutics

姜黄素-PLA 复合薄膜的制备及性能研究

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Preparation and Properties of Curcumin-PLA Composite Membranes

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摘要

结合流延法和溶剂蒸发技术制备聚乳酸(PLA) 含量分别为6%、10%和15%和姜黄素含量为0.8%和1.0%的可生物降解复合薄膜。考察了所制备的复合薄膜的形貌、红外光谱、孔隙率和力学性能,并探讨了复合薄膜中PLA 和姜黄素含量对体外释药的影响。研究表明,释药速率随PLA 含量的增加而减小,随含药量的增加而增大。与姜黄素原药相比,自制复合薄膜具有一定的缓释性能。

Abstract

The biodegradable composite membranes of curcumin with the content of 0.8% or 1% were prepared by casting and solvent evaporation method with different contents (6%, 10% and 15%) of polylactic acid (PLA) as the carrier. The morphology, infrared spectrum, porosity and mechanical property of the prepared composite membranes were investigated. The effects of PLA content and curcumin content on in vitro release were also discussed. The results showed that the release rate decreased with the increasing of PLA content and increased with the increasing of drug content.Compared with the curcumin powder, the prepared composite membranes demonstrated a sustained-release property.

关键词

姜黄素 / 聚乳酸 / 复合薄膜 / 制备 / 体外释放

Key words

curcumin / polylactic acid / composite membrane / preparation / in vitro release

引用本文

导出引用
郭 慧,吴济宏*. 姜黄素-PLA 复合薄膜的制备及性能研究. 中国医药工业杂志. 2013, 44(9): 896-899
GUO Hui, WU Jihong*. Preparation and Properties of Curcumin-PLA Composite Membranes. Chinese Journal of Pharmaceuticals. 2013, 44(9): 896-899

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