Paper
QI Muge , LI Gengsheng , GUO Zhonghua , WANG Xiaobing , MA Shuang , WEI Yage
An HPLC method was established for the simultaneous determination of the contents of nine
components(thymine, protocatechuic acid, vanillic acid, daidzin, scopoletin, genistin, daidzein, glycitein, and genistein)
in child compound endothelium corneum(CCEC) chewable tablets. This method was simple with good accuracy and
repeatability, which provided a comprehensive basis for the quality control of CCEC chewable tablets. Meanwhile, the
effects of CCEC chewable tablets on the rat models of functional dyspepsia(FD), food stagnation and anorexia were
investigated. The results showed that CCEC chewable tablets could enhance the activities of cholecystokinin(CCK)-8,
motilin(MTL), and pepsin in FD rats; increased the absorption rate of D-xylose, gastric pH, and pepsin activity in food
stagnation rats. It also improved the rates of gastric emptying, intestinal motility, and pepsin levels in anorexia rats. The
pharmacological research results indicated that CCEC chewable tablets had a significant therapeutic effect on functional
dyspepsia, which provided a certain pharmacological basis for its clinical application.