Paper
TANG Lu, LIU Xuyan, WANG Weiwei, WANG Wei, NI Feng, LI Jianqi
A GC method was established for the determination of the five residual organic solvents
(tetrahydrofuran, ethanol, acetonitrile, pyridine, N,N-dimethylformamide) and a related substance(1,3-propanediol) in
perampanel raw materials. Tetrahydrofuran, ethanol, acetonitrile, pyridine, N,N-dimethylformamide and 1,3-propanediol
were quantitatively determined by direct sampling on DB-WAX column, with DMSO as the solvent and temperature
programmed control. The above five organic solvents and 1,3-propanediol were completely separated. Their average
recoveries were 97.65% - 112.88%, with RSDs less than 5.0%. In the linearity test, good linear relationships between
peak areas and mass concentrations of the analytes were achieved, and all the correlation coefficients were more than
0.998.