建立了顶空毛细管气相色谱法同时测定利培酮中的甲醇、丙酮、异丙醇、乙腈、二氯甲烷、正己烷、乙酸乙酯和甲苯。采用DB-624毛细管色谱柱，程序升温，FID检测器，顶空平衡温度85 ℃，平衡时间20 min。上述溶剂分别在9～900、15～1 500、15～1 500、1.2～120、1.8～180、0.9～90、15～1 500和2.7～270 µg/ml浓度范围内线性关系良好，回收率分别为99.4％、96.4％、104.4％、99.7％、96.3％、96.3％、97.1％和96.8％，RSD均小于2.5％。

A headspace capillary gas chromatography method was established for the determination of methanol, acetone, isopropanol, acetonitrile, dichlormethane, hexane, ethyl acetate and toluene in risperidone. A DB-624 capillary column was used with temperature program and FID detector, at injection temperature of 85 ℃ and equilibrium time of 20 min. The calibration curves of these solvents were linear in the concentration ranges of 9 - 900, 15 - 1 500, 15 - 1 500, 1.2 - 120, 1.8 - 180, 0.9 - 90, 15 - 1 500 and 2.7 - 270 µg/ml, respectively. The recoveries were 99.4％, 96.4％, 104.4％, 99.7％, 96.3％, 96.3％, 97.1％ and 96.8％, with RSDs less than 2.5％.