微针递药系统治疗多种皮肤病的研究进展

魏微,赵锋,马银玲,鲍亚然,杜青

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主办:上海医药工业研究院
   中国药学会
   中国化学制药工业协会
ISSN 1001-8255   CN 31-1243/R   ZYGZEA
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中国医药工业杂志 ›› 2022, Vol. 53 ›› Issue (05) : 645-651. DOI: 10.16522/j.cnki.cjph.2022.05.007
专论与综述 Perspectives & Review

微针递药系统治疗多种皮肤病的研究进展

作者信息 +

Research Progress of Microneedle Drug Delivery Systems in Treatment of Various Skin Diseases

Author information +
History +

摘要

微针技术在皮肤病治疗中有独特的应用前景,具有自我给药、无痛微创、药物直达病灶、可控释药等特点,是皮肤治疗领域的研究热点,治疗优势明显。本综述着重介绍了微针在皮肤色斑、皮肤瘢痕、银屑病、皮肤损伤、皮癣等疾病的国内外治疗中的研究进展,并从药物、微针材料、疗效评价等方面详细论述,以期为皮肤病的治疗研究提供参考。

Abstract

Featured by self-administration, painless and minimally invasive surgery, direct drug delivery to the nidus, and controllable drug release, the microneedle technique enjoys a unique application prospect in treating dermatoses. Hence, it has become a research hotspot in dermatologic therapy and shows obvious therapeutic advantages. This review focuses on introducing the progress of researches at home and abroad on the treatment of hyperpigmentation, cicatrix, psoriasis, skin injury and tinea by microneedles, and further elaborates the perspectives of medicines, microneedle materials, and evaluations on therapeutic effects to provide a reference for skin disease treatment research.

关键词

微针 / 经皮递药 / 皮肤病 / 微创治疗 / 治疗评价

Key words

microneedle / transdermal drug delivery / skin disease / minimally invasive therapy / treatment evaluation

引用本文

导出引用
魏微,赵锋,马银玲,鲍亚然,杜青. 微针递药系统治疗多种皮肤病的研究进展. 中国医药工业杂志. 2022, 53(05): 645-651 https://doi.org/10.16522/j.cnki.cjph.2022.05.007
WEI Wei, ZHAO Feng, MA Yinling, BAO Yaran, DU Qing. Research Progress of Microneedle Drug Delivery Systems in Treatment of Various Skin Diseases. Chinese Journal of Pharmaceuticals. 2022, 53(05): 645-651 https://doi.org/10.16522/j.cnki.cjph.2022.05.007

参考文献

[1] DASHT BOZORG B, BHATTACCHARJEE S A,SOMAYAJI M R, et al.Topical and transdermal delivery with diseased human skin: passive and iontophoretic delivery of hydrocortisone into psoriatic and eczematous skin [J].Drug Deliv Transl Res, 2022, 12(1): 197-212.
[2] HAY R J, JOHNS N E, WILLIAMS H C, et al.The global burden of skin disease in 2010: an analysis of the prevalence
and impact of skin conditions [J].J Invest Dermatol, 2014,134(6): 1527-1534.
[3] 申国庆.掌握多种差异性 合理使用皮肤外用药[J].药学与临床研究, 2015, 23(6): 626-628.
[4] 何雪瑜, 许 珂, 陈慕刁, 等.慢性皮肤病患者皮肤外用药使用知识和行为现状调查[J].广州医科大学学报, 2019,47(3): 176-178.
[5] DALGARD F J, GIELER U, TOMAS-ARAGONES L, et al.The psychological burden of skin diseases: a crosssectional multicenter study among dermatological outpatients in 13 European countries [J].J Invest Dermatol,2015, 135(4): 984-991.
[6] SABRI A H, OGILVIE J, ABDULHAMID K, et al.Expanding the applications of microneedles in dermatology[J].Eur J Pharm Biopharm, 2019, 140: 121-140.
[7] CARY J H, LI B S, MAIBACH H I.Dermatotoxicology of microneedles(MNs) in man [J].Biomed Microdevices,2019, 21(3): 66-74.
[8] PURI A , NGUYEN H X , TI J A N I A O , e t a l.Characterization of microneedles and microchannels for enhanced transdermal drug delivery [J].Ther Deliv, 2021,12(1): 77-103.
[9] YANG D, CHEN M L, SUN Y, et al.Microneedle-mediated transdermal drug delivery for treating diverse skin diseases[J].Acta Biomater, 2021, 121: 119-133.
[10] YANG J, LIU X L, FU Y Z, et al.Recent advances of microneedles for biomedical applications: drug delivery and beyond [J].Acta Pharm Sin B, 2019, 9(3): 469-483.
[11] VORA L K, MOFFATT K, TEKKO I A, et al.Microneedle array systems for long-acting drug delivery [J].Eur J Pharm Biopharm, 2021, 159: 44-76.
[12] DONNELLY R F, SINGH T R R, ALKILANI A Z, et al.Hydrogel-forming microneedle arrays exhibit antimicrobial properties: potential for enhanced patient safety [J].Int J Pharm, 2013, 451(1/2): 76-91.
[13] KAISER P, W?CHTER J, WINDBERGS M.Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems [J].Drug Deliv Transl Res, 2021,11(4): 1545-1567.
[14] YI X, WANG C Y, YU X, et al.Chitosan/zinc nitrate microneedles for bacterial biofilm eradication [J].J Biomed Mater Res B Appl Biomater, 2020, 109(6): 911-920.
[15] WANG Y S, YANG W H, GAO W, et al.Combination and efficiency: preparation of dissolving microneedles array loaded with two active ingredients and its anti-pigmentation effects on guinea pigs [J].Eur J Pharm Sci, 2021, 160:105749.
[16] 张楚晗, 刘笑芬, 张 菁, 等.多黏菌素B诱发皮肤色素沉着的机制研究[J].中国感染与化疗杂志, 2020, 20(3):331-334.
[17] 杨 益, 刘 陶, 朱 姗, 等.中药治疗皮肤色素沉着类疾病研究进展 [J].辽宁中医药大学学报, 2020, 22(10):115-119.
[18] COUTEAU C, COIFFARD L.Overview of skin whitening agents: drugs and cosmetic products [J].Cosmetics, 2016,3(3): 27-43.
[19] LEE C A, BAEK J S, KWAG D G, et al.Enhancement of skin permeation of vitamin C using vibrating microneedles[J].Transl Clin Pharmacol, 2017, 25(1): 15-20.
[20] AUNG N N, NGAWHIRUNPAT T, ROJANARATA T, et al.HPMC/PVP dissolving microneedles: a promising delivery platform to promote trans-epidermal delivery of alpha-arbutin for skin lightening [J].AAPS PharmSciTech,2019, 21(1): 25.
[21] SALCIDO R S.The cicatrix: the functional stage of wound healing [J].Adv Skin Wound Care, 2018, 31(1): 581.
[22] CARMASSI M, ERAUD J, GONELLI D, et al.Keloid scars: a case series study [J].Ann Pathol, 2015, 35(2):148-153.
[23] BAYAT A, MCGROUTHER D A, FERGUSON M W J.Skin scarring [J].BMJ, 2003, 326(7380): 88-92.
[24] LEE S S, YOSIPOVITCH G, CHAN Y H, et al.Pruritus,pain, and small nerve fiber function in keloids: a controlled study [J].J Am Acad Dermatol, 2004, 51(6): 1002-1006.
[25] MARI W, ALSABRI S G, TABAL N, et al.Novel insights on understanding of keloid scar: article review [J].J Am Coll Clin Wound Spec, 2016, 7(1-3): 1-7.
[26] PARK J, KIM Y C.Topical delivery of 5-fluorouracil-loaded carboxymethyl chitosan nanoparticles using microneedles for
keloid treatment [J].Drug Deliv Transl Res, 2021, 11(1):205-213.
[27] TAN C W X, TAN W D, SRIVASTAVA R, et al.Dissolving triamcinolone-embedded microneedles for the treatment of keloids: a single-blinded intra-individual controlled clinical trial [J].Dermatol Ther(Heidelb), 2019, 9(3): 601-611.
[28] EL-DOMYATI M, BARAKAT M, AWAD S, et al.Microneedling therapy for atrophic acne scars: an objective evaluation [J].J Clin Aesthet Dermatol, 2015, 8(7): 36-42.
[29] SITOHANG I B S, SIRAIT S A P, SURYANEGARA J.Microneedling in the treatment of atrophic scars: a systematic review of randomised controlled trials [J].Int Wound J,2021, 18(5): 577-585.
[30] TAKESHITA J, GREWAL S, LANGAN S M, et al.Psoriasis and comorbid diseases: epidemiology [J].J Am Acad Dermatol, 2017, 76(3): 377-390.
[31] GRIFFITHS C E, BARKER J N.Pathogenesis and clinical features of psoriasis [J].Lancet, 2007, 370(9583): 263-271.
[32] HU S C, CHEN G S, TU H P.Epidemiology of depression in patients with psoriasis: a nationwide population-based
cross-sectional study [J].Acta Derm Venereol, 2019,99(6): 530-538.
[33] DU H Y, LIU P, ZHU J J, et al.Hyaluronic acid-based dissolving microneedle patch loaded with methotrexate for improved treatment of psoriasis [J].ACS Appl Mater Interfaces, 2019, 11(46): 43588-43598.
[34] YU K Y, YU X M, CAO S S, et al.Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis [J].Acta Pharm Sin B, 2021, 11(2): 505-519.
[35] KAISER P, W?CHTER J, WINDBERGS M.Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems [J].Drug Deliv Transl Res, 2021, 11(4): 1545-1567.
[36] PANDA A, SHETTAR A, SHARMA P K, e t a l.Development of lysozyme loaded microneedles for dermal applications [J].Int J Pharm, 2021, 593: 120104.
[37] PERMANA A D, ANJANI Q K, SARTINI, et al.Selective delivery of silver nanoparticles for improved treatment of biofilm skin infection using bacteria-responsive microparticles loaded into dissolving microneedles [J].Mater Sci Eng C Mater Biol Appl, 2021, 120: 111786.
[38] ARSHAD M S, ZAHRA A T, ZAFAR S, et al.Antibiofilm effects of macrolide loaded microneedle patches: prospects in
healing infected wounds [J].Pharm Res, 2021, 38(1): 165-177.
[39] GUPTA M, GOYAL A K, PALIWAL S R, e t a l.Development and characterization of effective topical liposomal system for localized treatment of cutaneous candidiasis [J].J Liposome Res, 2010, 20(4): 341-350.
[40] GUéGAN S, LANTERNIER F, ROUZAUD C, et al.Fungal skin and soft tissue infections [J].Curr Opin Infect Dis, 2016, 29(2): 124-130.
[41] WANG F Y, ZHANG X X, CHEN G P, et al.Living bacterial microneedles for fungal infection treatment [J].Research(Wash D C), 2020, 2020: 2760594.
[42] JAMALEDIN R, YIU C K Y, ZARE E N, et al.Advances in antimicrobial microneedle patches for combating infections[J].Adv Mater, 2020, 32(33): e2002129.
[43] PERMANA A D, PAREDES A J, VOLPE-ZANUTTO F,et al.Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis [J].Eur J Pharm Biopharm, 2020,154: 50-61.

基金

河北省自然科学基金项目( H 2 0 2 0 2 0 6 4 5 1 、 H2020307043)、河北省卫生厅医学科学研究重点课题(20170472)

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