皮肤局部给药中新载体技术的研究与应用

杨晓钰,罗华菲

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主办:上海医药工业研究院
   中国药学会
   中国化学制药工业协会
ISSN 1001-8255   CN 31-1243/R   ZYGZEA
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中国医药工业杂志 ›› 2022, Vol. 53 ›› Issue (05) : 639-644. DOI: 10.16522/j.cnki.cjph.2022.05.006
专论与综述 Perspectives & Review

皮肤局部给药中新载体技术的研究与应用

作者信息 +

Research and Application of New Carrier Technology in Transdermal and Topical Drug Delivery

Author information +
History +

摘要

皮肤给药是治疗皮肤相关疾病的重要方法,具有优势的同时也存在局限性。多微泡分散体、微海绵等新载体的研发与应用能够改善皮肤给药的复方制剂中不同活性成分的稳定性、提高载药量,新型黏附剂能够使贴剂更持久地黏附在皮肤表面进而实现药物持续递送。本研究选取FDA 近几年来批准上市的皮肤给药制剂,对其采用的新载体技术进行介绍,以期对未来皮肤局部外用制剂的研究提供参考。

Abstract

Transdermal drug delivery is an important drug delivery route for treating skin-related diseases, which has both advantages and limitations. The development and application of new carriers such as multi-microbubble dispersion and microsponges can improve stability and drug loading of different active ingredients in compound preparations for transdermal administration. The new adhesives can make patches enduringly adhere to the skin surface to realize continuous drug delivery. In this review, the dermatological preparations approved by FDA are selected, and the new carrier technologies are introduced, which might provide a reference for future research on topical and transdermal formulations.

关键词

皮肤局部给药 / 载体 / 多微泡分散体 / 微海绵 / 黏附给药系统

Key words

transdermal and topical drug delivery / carrier / multi-microbubble dispersion / microsponge / adhesive drug delivery system

引用本文

导出引用
杨晓钰,罗华菲. 皮肤局部给药中新载体技术的研究与应用. 中国医药工业杂志. 2022, 53(05): 639-644 https://doi.org/10.16522/j.cnki.cjph.2022.05.006
YANG Xiaoyu, LUO Huafei. Research and Application of New Carrier Technology in Transdermal and Topical Drug Delivery. Chinese Journal of Pharmaceuticals. 2022, 53(05): 639-644 https://doi.org/10.16522/j.cnki.cjph.2022.05.006

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