影响注射用长效纳米晶混悬型注射液体内外释药因素的概述

丁静雯,王君吉,何军

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主办:上海医药工业研究院
   中国药学会
   中国化学制药工业协会
ISSN 1001-8255   CN 31-1243/R   ZYGZEA
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中国医药工业杂志 ›› 2020, Vol. 51 ›› Issue (12) : 1517-1528. DOI: 10.16522/j.cnki.cjph.2020.12.005
专论与综述 Perspectives & Review

影响注射用长效纳米晶混悬型注射液体内外释药因素的概述

作者信息 +

An Overview of Factors Affecting in vivo and in vitro Release of Long-acting Injection of Nanocrystal Suspensions

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摘要

近年来,长效纳米晶混悬型注射液(LAI-NS) 凭借其在慢性疾病( 如精神疾病、艾滋病病毒感染) 治疗方面的优势而成为研究热点。本文综述了影响LAI-NS 体内外释放的因素,介绍其体外释放与体内外相关性的评价方法。同时,简要介绍了局部组织炎症反应不同阶段对LAI-NS 中药物颗粒吸收进入体循环的影响,以及局部组织成像技术在LAI-NS 质量评价中的应用进展。期望本文能为建立LAI-NS 的体内外相关性模型及质量评价体系提供参考。

Abstract

In recent years, long-acting injection of nanocrystal suspensions(LAI-NS) has become a research hotspot due to its advantages in the treatment of chronic diseases[such as mental illness and human immunodeficiency virus(HIV) infection]. This paper reviews the factors affecting the in vitro and in vivo release of LAI-NS, introduces the evaluation methods for in vitro release and in vivo-in vitro correlation(IVIVC). The influence factors on drug-loaded particles entering systemic circulation during local tissue inflammation process and the advances in application of local tissue imaging technology in quality evaluation of LAI-NS are briefly introduced. It is expected that this paper can provide some references for establishing IVIVC models and quality evaluation system of LAI-NS.

关键词

长效纳米晶混悬型注射液 / 体外释放 / 体内外相关性 / 局部组织炎症 / 成像技术

Key words

long-acting injection of nanocrystal suspension / in vitro release / in vivo-in vitro correlation(IVIVC) / local tissue inflammation / imaging technology

引用本文

导出引用
丁静雯,王君吉,何军. 影响注射用长效纳米晶混悬型注射液体内外释药因素的概述. 中国医药工业杂志. 2020, 51(12): 1517-1528 https://doi.org/10.16522/j.cnki.cjph.2020.12.005
DING Jingwen, WANG Junji, HE Jun. An Overview of Factors Affecting in vivo and in vitro Release of Long-acting Injection of Nanocrystal Suspensions. Chinese Journal of Pharmaceuticals. 2020, 51(12): 1517-1528 https://doi.org/10.16522/j.cnki.cjph.2020.12.005

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