主办:上海医药工业研究院
   中国药学会
   中国化学制药工业协会
ISSN 1001-8255   CN 31-1243/R   ZYGZEA
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    Hu Pan, Wu Xiaofan, Huang Zedu, Chen Fener,
    Chinese Journal of Pharmaceuticals.
    Accepted: 2024-12-06
    As environmentally benign and sustainable technologies, enzyme immobilization and continuous flow synthesis have been widely applied to organic synthesis. In recent years, immobilized enzyme based flow biocatalysis has received increasing attention and application, because it possesses the integrated advantages of enzyme immobilization and continuous flow synthesis. Ketoreductase-catalyzed asymmetric reduction of prochiral ketones is one of the most effective methods for the synthesis of chiral alcohols. This paper summarizes the research progress of immobilized ketoreductase in continuous flow synthesis, and provides guidance for developing efficient, economic, and sustainable flow biocatalysis approaches.