ZHAO Ying, XU Kexin, HU Hao, WANG Huimei, WANG Lianyan
Chinese Journal of Pharmaceuticals.
In the treatment of bladder dysfunctional diseases and bladder tumors, as an emerging therapeutic strategy, nanotechnology provides promising applications for efficient drug delivery in vivo due to its effective size effect and targeting modifications. As an effective administration route for the treatment of bladder diseases, intravesical instillation shows superior efficacy compared with systemic administration. However, periodic urination flushes out the instilled drug, resulting in a reduced duration of action. In addition, the existence of a bladder permeability barrier limits drug penetration into the inflammatory sites and tumor tissues. Therefore, it is crucial to develop a novel nano-drug delivery system. This study reviews research related to nano-drug delivery systems for the treatment of bladder dysfunctional diseases and bladder tumors, with the aim of providing more ideas and methods for improvement of clinical treatments in the future.