Paper
ZHANG Yiming, RAN Qijun, CHENG Cheng, TANG Lei, WANG Jianta, ZHU Gaofeng
In order to perform the quality control of ursodeoxycholic acid, seven related substances were
synthesized. 3,7-Dioxocholanoic acid, 7α-hydroxy-3-oxocholanoic acid, 7-oxolithocholic acid, 3-hydroxy-6-oxocholanoic
acid, 3,6-dioxocholanoic acid, 3-oxocholanoic acid and 3β,7α-dihydroxycholanoic acid were synthesized from
chenodeoxycholic acid, hyodeoxycholic acid, or lithocholic acid via oxidation, esterification, acylation and reduction.
The yields were 68%, 17%, 74%, 60%, 76%, 70% and 15%, respectively. The chemical structures of above related
substances were confirmed by NMR and HRMS.