Paper
QIU Hao, QIU Shoushuai, WANG Yiwen, CHEN Ranzhang, CHENG Qingfang
In order to control the quality of rosuvastatin calcium, five related substances of rosuvastatin
calcium were synthesized: [(3R,5S,E)-7-[4-(4-fluorophenyl)-2-[[2-[4-(4-fluorophenyl)-6-isopropyl-2-[Nmethyl(
methanesulfonamido)]pyrimidin-5-yl]-2-hydroxyethyl]-N-methylsulfonamido]-6-isopropylpyrimidin-5-yl]-
3,5-dihydroxyhept-6-enoate] calcium salt(related substance A), [(3R,5S,E)-7-[4-(4-fluorophenyl)-2-[[(E)-2-[4-
(4-fluorophenyl)-6-isopropyl-2-[N-methyl(methanesulfonamido)]pyrimidine-5-yl]vinyl]-N-methylsulfonamide]-
6-isopropylpyrimidin-5-yl]-3,5-dihydroxyheptyl-6-enoate] calcium salt(related substance B), N-[4-(4-
fluorophenyl)-5-[(E)-2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]vinyl]-6-isopropylpyrimidin-2-yl]-Nmethylmethanesulfonamide(
related substance C), N-[(R)-8-fluoro-6-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-
yl]-4-isopropyl-5,6-dihydrobenzo[h]quinazolin-2-yl]-N-methylmethanesulfonamide(related substance D), and N-[(S)-
8-fluoro-6-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]-4-isopropyl-5,6-dihydrobenzo[h]quinazolin-2-yl]-Nmethylmethanesulfonamide(
related substance E). And their structures were confirmed by MS, 1H NMR and the optical
rotation.