中国医药工业杂志
 
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CJPH  2013, Vol. 44 Issue (3): 226-227    DOI:
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One-step Synthesis of Piracetam
Shanghai Modern Hasen Shangqiu Pharmaceutcal Co., Ltd., Shangqiu 476000
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Abstract With absolute ethanol as the solvent, ethyl 4-chloro-n-butanoate and glycinamide hydrochloride were refluxed for 20 h in the presence of sodium bicarbonate to obtain central stimulant piracetam. After recrystallization from isopropanol, the yield was about 58% with a purity of 99.6%.
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Key wordspiracetam   central stimulant   ethyl 4-chloro-n-butanoate   glycinamide hydrochloride   synthesis     
Cite this article:   
. One-step Synthesis of Piracetam[J]. CJPH, 2013, 44(3): 226-227.
 
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