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Green Synthesis and Optimization of Celecoxib Catalyzed by Micro-nanometer Potassium Carbonate
FENG Juan, FU Wenna, WANG Jingkun, WANG Cuicui, LIU Shouxin
PDF(39897 KB)
PDF(39897 KB)
Green Synthesis and Optimization of Celecoxib Catalyzed by Micro-nanometer Potassium Carbonate
celecoxib / green synthesis / Claisen condensation / micro-nanometer potassium carbonate / “one-pot method” {{custom_keyword}} /
[1] MEYERS C, MAES B U, LOONES K T, et al．Study of a new rate increasing "base effect" in the palladium-catalyzed amination of aryl iodides [J]．J Org Chem, 2004, 69(18): 6010-6017．
[2] 李军章．纳米碳酸盐的制备及其化学反应行为的研究 [D]．天津: 河北工业大学硕士学位论文，2013．
[3] LI J Z, FAN S M, SUN X F, et al．Nano-K2CO3: preparation, characterization and evaluation of reactive activities [J]． RSC Adv, 2016, 6(3): 1865-1869．
[4] XUE H, FAN S M, XU J Z, et al．Total synthesis and stereochemistry establishment of tumescenamide A [J]．Org Chem Front, 2022, 9(6): 1675-1679．
[5] 李军章, 刘 敏．苯基-(3,5- 二叔丁基-4- 羟基苄基) 丙 二酸二(1,2,2,6,6- 五甲基-4- 哌啶) 酯的合成[J]．精细化 工, 2014, 31(1): 94-98．
[6] GUERRANT W, KOTA S, TROUTMAN S, et al．YAP mediates tumorigenesis in neurofibromatosis type 2 by promoting cell survival and proliferation through a COX-2- EGFR signaling axis [J]．Cancer Res, 2016, 76(12): 3507- 3519．
[7] ALSAEGH H, EWEIS H, KAMAL F, et al．Celecoxib decrease seizures susceptibility in a rat model of inflammation by inhibiting HMGB1 translocation [J]． Pharmaceuticals(Basel), 2021, 14(4): 380．
[8] LEBEDEVA E S, KUZUBOVA N N, TITOVA O N, et al． Effect of cyclooxygenase-2 inhibition on lung inflammation and hypoxia-inducible factor-1 signalling in COPD model [J]．Eur Respir J, 2017, 50: 3926．
[9] PENNING T D, TALLEY J J, BERTENSHAW S R, et al． Synthesis and biological evaluation of the 1,5-diarylpyaxole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl]benzenesulfonamide(SC-58635, celecoxib) [J]．J Med Chem, 1997, 40(9): 1347-1365．
[10] 梅之南, 施 震, 汪细和, 等．COX-2 抑制剂Celecoxib 的 合成[J]．中国医药工业杂志, 2000, 31(10): 433-434．
[11] GAO M Z, WANG M, MILLER K D, et al．Synthesis and preliminary in vitro biological evaluation of new carbon-11- labeled celecoxib derivatives as candidate PET tracers for imaging of COX-2 expression in cancer [J]．Eur J Med Chem, 2011, 46(9): 4760-4767．
[12] ŚWIĄTEK K, JARZYŃSKA G U, PALUSIAK M, et al． One-pot synthesis of 1-aryl-3-trifluoromethylpyrazoles using nitrile imines and mercaptoacetaldehyde as a surrogate of acetylene [J]．Org Lett, 2023, 25(24): 4462-4467．
[13] DAVIES T Q, TILBY M J, SKOLC D, et al．Primary sulfonamide synthesis using the sulfinylamine reagent N-Sulfinyl-O-(tert-butyl) hydroxylamine, t-BuONSO [J]． Org Lett, 2020, 22(24): 9495-9499．
[14] MURRAY B J, MARSH T G F, YUFIT D S, et al．HFO- 1234yf as a CF3-building block: synthesis and chemistry of CF3-ynones [J]．Eur J Org Chem, 2020, 2020(39): 6236- 6244．
[15] SCHOLTZ C, RILEY D L．Improved batch and flow syntheses of the nonsteroidal anti-inflammatory COX-2 inhibitor celecoxib[J]．React Chem Eng, 2021, 6(1): 138- 146．
[16] 唐龙骞, 赵彦伟, 孟昭力．COX-2 抑制剂celecoxib 的合成 工艺改进[J]．中国药物化学杂志, 2003, 13(1): 44-45．
[17] STHALAM V K, SINGH A K, PABBARAJA S．An integrated continuous flow micro-total ultrafast process system(μ-TUFPS) for the synthesis of celecoxib and other cyclooxygenase inhibitors [J]．Org Process Res Dev, 2019, 23(9): 1892-1899．
[18] LILL A, KLAUS S, HOLGER S．Synthesis of novel dansyllabeled celecoxib derivatives [J]．Tetrahedron Lett, 2013, 54(49): 6682-6686
[19] 吕苗苗, 陈华宝, 李海泉, 等．塞来昔布的合成[J]．北 京化工大学学报( 自然科学版), 2005, 32(6): 97-98．
[20] 王经坤．塞来昔布合成工艺的改进及类似物的合成[D]． 石家庄: 河北科技大学硕士学位论文，2014．
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