Anti-tumor Natural Products Acting on AP-1 Signaling Pathway

LI Xia, SUN Qingyan, ZHANG Weidong

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主办:上海医药工业研究院
   中国药学会
   中国化学制药工业协会
ISSN 1001-8255   CN 31-1243/R   ZYGZEA
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Chinese Journal of Pharmaceuticals ›› 2020, Vol. 51 ›› Issue (03) : 305-315. DOI: 10.16522/j.cnki.cjph.2020.03.001
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Anti-tumor Natural Products Acting on AP-1 Signaling Pathway

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Abstract

Activator protein-1(AP-1) is an important transcriptional regulator composed of DNAbinding proteins involved in several cellular processes responsible for cell survival, proliferation and differentiation. Overactivation of AP-1 leads to increased expression of downstream proteins associated with tumor invasion and metastasis, which plays a key role in tumor invasion and metastasis. Therefore, targeting and inhibiting AP-1 has recently developed as an attractive therapeutic strategy for cancer prevention and therapy. This paper reviews our current understanding of the structure and function of AP-1, and discusses the anti-tumor effects and action mechanisms of several natural active compounds reported in recent years by regulating AP-1 associated signaling pathways.

Key words

natural product / activator protein-1 / transcription factor / signaling pathway / tumor invasion and metastasis

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LI Xia, SUN Qingyan, ZHANG Weidong. Anti-tumor Natural Products Acting on AP-1 Signaling Pathway. Chinese Journal of Pharmaceuticals. 2020, 51(03): 305-315 https://doi.org/10.16522/j.cnki.cjph.2020.03.001

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