A near-infrared spectroscopy was used to analyze three crystal forms of furosemide, and the reference spectra were established. The quantitative model of furosemide crystal form was established by OPUS data analysis system. Partial least-squares (PLS) regression models were developed, and different data preprocessing algorithms such as linear compensation subtraction method, linear difference subtraction method, vector normalization method, minimummaximum normalization method, multiple scattering correction method and 1st to 2nd derivatives were applied to reduce the influence of systematic disturbances. The root mean square error of cross validation (RMSECV) of the quantitative model established for form Ⅰ, Ⅱ and Ⅲ was 1.51, 2.03 and 2.23, their determination coefficient R2 was 99.73, 99.43 and 99.16, and the rank was 9, 6 and 8, respectively. Their LODs were 1.58％, 1.35％ and 0.67％, and their LOQs were 4.74％, 4.05％ and 2.01％, respectively.
Key words
furosemide /
polymorphism /
near infrared spectroscopy /
quantitative analysis
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References
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