HPLC Determination of Irganox 1310 in Sodium Chloride Injection in Three-layer Co-extrusion Bags

ZHOU Yaju, ZHANG Fangfang

主办:上海医药工业研究院
   中国药学会
   中国化学制药工业协会
ISSN 1001-8255   CN 31-1243/R   ZYGZEA
Chinese Journal of Pharmaceuticals ›› 2016, Vol. 47 ›› Issue (05) : 618. DOI: 10.16522/j.cnki.cjph.2016.05.023

HPLC Determination of Irganox 1310 in Sodium Chloride Injection in Three-layer Co-extrusion Bags

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Abstract

An HPLC method was established for the determination of 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid (Irganox 1310) in sodium chloride injection packaged in three-layer co-extrusion bags. The study was carried out with Eclipse C18 column and acetonitrile (containing 0.1% acetic acid)∶0.1% acetic acid (60∶40) as mobile phase. The detection wavelength was 210 nm. The results showed that it was linear for Irganox 1310 in the range of 0.4—100 μg/ml. The recoveries were 94%—106% with RSDs less than 4%.

Key words

three-layer co-extrusion bag / sodium chloride injection / Irganox 1310 / HPLC

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ZHOU Yaju, ZHANG Fangfang. HPLC Determination of Irganox 1310 in Sodium Chloride Injection in Three-layer Co-extrusion Bags. Chinese Journal of Pharmaceuticals. 2016, 47(05): 618 https://doi.org/10.16522/j.cnki.cjph.2016.05.023

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