To improve the solubility of felodipine (1), solid dispersions (SD) were prepared by solvent method with polyvidone (PVP) K29/32 as a carrier at three different drug/carrier weight ratios of 1∶2, 1∶4 and 1∶6. The results of differential scanning calorimetry and X-ray diffraction analysis indicated that the drug existed in an amorphous form in the three prepared SDs. Compared with physical mixture and the bulk drug, all SDs significantly increased the dissolution of 1. Four kinds of hydrophilic matrix sustained-release tablets based on the above three SDs and the bulk drug were respectively prepared. The similarities in release profiles between four self-made products and Plendil in 1％ Tween-80 solution were investigated. The results showed that the calculated similar factor (f2) value between the tablets based on SD with drug/carrier weight ratio of 1∶6, named as product c, and Plendil was 70. Furthermore, the f2 values between product c and Plendil were all above 50 according to the release profiles in water and media with different pH values (1.0, 4.5 and 6.8). The pharmacokinetics of these two preparations in Beagle dogs were investigated. The drug concentration was determined by LC-MS. The results showed that two preparations were bioequivalent in Beagle dogs. The relative bioavailability of product c was 103.5％.