Paper
ZHANG Zhen, WANG Guan, QIU Yongfu, LIU Xuyan, LI Jianqi
In order to control the quality of ivabradine hydrochloride, five related substances were prepared: 7,8-dimethoxy-3-propyl-1,3-dihydro-2H-benzo[d]azepin-2-one(related substance A), 3-allyl-7,8-dimethoxy-1,3-dihydro- 2H-benzo[d]azepin-2-one(related substance B), 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]- azepin-2-one)(related substance C), (S)-[2-[2-[[3-[[[3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl]methyl]- (methyl)amino]propyl]amino]ethyl]-4,5-dimethoxyphenyl]acetic acid(related substance D), 3-(7,8-dimethoxy-2-oxo- 1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-N-[[(S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-triene-7-yl]methyl]- N-methylpropan-1-amine oxide(related substance E). The structures were confirmed by MS and 1 H NMR. Among them, both related substance A and B have not found in literature.