LIU Qing1, WANG Jinmin2, ZHAO Guolei2, LAI Yisheng1*
Lu r a s i d o n e h y d r o c h l o r i d e wa s s y n t h e s i z e d f r om (1R, 2R)- c y c l o h e x a n e - 1 , 2 - dicarboxylic acid by chlorination, esterification, reduction, and sulfonylation to give (1R,2R)-1,2-bis(4- toluenesulfonyloxymethyl)cyclohexane, which was subjected to condensation with 3-(piperazin-1-yl)benzo[d]- isothiazole, followed by reaction with (3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione and salification with hydrochloric acid. The overall yield was about 36%.