LUO Jing1, ZHANG Tao2,3, HUANG Hua1*, DING Yan-Ji2,3, LIU Ze-Rong2,3
2012, 43(2): 107-111.
The loxoprofen sodium cataplasm was prepared with water-soluble polymer material partially neutralized polyacrylate (NP700) as matrix, polyvinylpyrrolidone K90 and carboxymethylcellulose sodium as viscosityenhancing agents and gelatin as film forming material. The formulation was optimized by orthogonal design. The product could completely release in 2 h. The transdermal behavior through excised Bama miniature pig skin fitted to zero-order kinetics equation. The cumulative transdermal amount of cataplasm containing combined permeation enhancers was significantly higher than that of the blank group (containing no permeation enhancer) and other groups (containing a single permeation enhancer). The results of preliminary stability study showed that the adhesion, content, in vitro release and transdermal property of the product stored at 30 ℃ and 60% relative humidity for 6 months had no significant
change.