JIANG Meng-Yin1,2, MIAO De-Yu1, CHEN Jun2, CAO Lin3, LI Wei1*
2012, 43(3): 197-200.
Twenty healthy female volunteers were given a single oral dose of levonorgestrel tablets in a randomized crossover study. Serum levels of the drug were determined by radioimmunoassay method. The pharmacokinetics of test and reference preparation were as follows: tmax (1.9±0.2) and (2.0±0.1) h, cmax (6.34±1.16) and (6.86±1.07 ) ng/ml, MRT (30.48±4.85) and (29.26±4.71) h, t1/2 (24.60±4.28) and (24.12±4.61) h, AUC0→72 h (92.43± 24.24) and (101.09±31.21) h·ng·ml-1, AUC0→∞ (104.41±29.25) and (113.06±36.07) h·ng·ml-1, respectively. The relative bioavailability of the test preparation was (93.5±16.2)%.